The role of mhc relatedness in female lab mouse m musculus mate preference

A review of mhc-based mate preferences and fostering experiments in two congenic strains of mice social behavior, reproduction and population changes in the house mouse ( mus musculus ) brown, rz sex ratio manipulation in color-banded populations of zebra finches female mate preference enhances offspring growth and reproduction in a. Perhaps the most likely explanation for this finding is that a wider baculum facilitates increased stimulation of the female reproductive tract and further validated with reference to major histocompatibility complex (mhc) and major urinary an intraspecific study in the house mouse (mus musculus domesticus) genetica 2010, 138: 129. In several species, including rodents and fish, it has been shown that the major histocompatibility complex (mhc) influences mating preferences and, in some cases, that this may be mediated by preferences based on body odour in humans, the picture has been less clear several studies have reported. Female choice for male ornamental traits is widely accepted as a mechanism by which females maximize their reproductive success and/or offspring quality however, there is an increasing empirical literature that shows a fitness benefit of genetic diversity and a tendency for females to use genetic dissimilarity as a criterion for mate choice.

the role of mhc relatedness in female lab mouse m musculus mate preference 1 introduction the major histocompatibility complex (mhc) is an extremely polymorphic cluster of genes that encode antigen-presenting molecules of central importance in vertebrate adaptive immunity.

Most of these studies have shown a link between genetic relatedness at major histocompatibility complex (mhc) loci and body scent [11,17,19,21,22] the mhc is an extremely polymorphic complex of genes that plays a critical role in immune response and disease resistance. The mhc loci of vertebrates play a critical role in the immune system but also function in mate choice, such that mhc diversity may be generated by both parasite pressure and disassortative mating (reviewed in [80, 81]. The mhc, but not diversity or relatedness at other loci, has also been implicated in mate choice in cooperatively breeding seychelles warblers here, females seek egp if their social partner has low mhc diversity, which in turn is linked to offspring survival (brouwer et al , 2010 .

In laboratory mice, female preference for airborne urinary scents from males (detected through the main olfactory system) is learnt through association with scents detected through the vomeronasal system during contact with the scent source. (b) controlled natural mating experiment this experiment allowed us to test the effect of relatedness and mhc similarity between partners on the amount of sperm that reached the females' eggs while reducing female precopulatory mate choice bias by allowing only predetermined, staged matings to occur. Preference in male and female house mice miriam linnenbrink and sophie as well as dyadic factors (eg neutral genetic distance and major histocompatibility complex (mhc) dissimilarity) that direct partner preferences mate choice, mus musculus domesticus, mhc, familial imprinting background in social animals, individuals interact with.

Subsequently, the laboratory mouse arose as a hybrid of various mus lineages (m musculus, m domesticus, and and possibly m bactrianus and m castaneus) geneticists have bred many different strains of laboratory mice. September 12, 2007 time: 01:06am t1-v11 scent, mate choice and genetic heterozygosity 295 01 whether the role of mhc in mate choice is related specifically to its involvement 02 in immune defence, or because this region is a reliable signal for overall genetic 03 similarity, the failure of most studies to separate the effects of mhc and. This occurs in other species, such as humans, and in the context of the mouse cage, there is limited opportunity for the male mouse to escape a mate-guarding female however, this explanation would predict a positive correlation between dominance and reproductive success, which we did not find.

Mate choice is a critical behavioral decision process with profound impact on evolution however, the mechanistic basis of mate choice is poorly understood in this study we focused on assortative mate choice, which is known to contribute to the reproductive isolation of the two european subspecies of house mouse, mus musculus musculus and mus musculus domesticus. Despite the lack of direct evidence for mhc-mediated mate choice, we did find a correlation between mhc diversity and reproductive success for some mate pair classes at specific mhc-linked microsatellites. Conclusions this involatile protein is a mammalian male sex pheromone that stimulates a flexible response to individual-specific odours through associative learning and memory, allowing female sexual attraction to be inherent but selective towards particular males. Such a pattern suggests that whenever the two subspecies meet, female m m musculus would tend to be mated by m m domesticus males, and in light of our results male m m domesticus may tend to mate more readily with female m m musculus only when females of their subspecies are rare or absent, ie during migration. Ryon, j and brown, re urine-marking in female wolves (canis lupus): an indicator of dominance status and reproductive state r, schellinck, h, brown, r and roser, b evolutionary and immunological implications of the role of the mhc in olfactory signalling r e the discrimination of human male urine odors by rats is not.

The role of mhc relatedness in female lab mouse m musculus mate preference

All six combinations of line and female treatments showed a trend toward preference for outbred males (table 1, fig 2) although only the outbred jon female treatment showed a significant preference individually (p = 00093, two-tailed binomial test. A number of factors may influence a male’s quality as a mate, in particular competitive ability, disease resistance and relatedness to the female competition between males results in the most competitive males accruing the most resources and highest social status. The first study to examine mhc-dependent mate selection in humans was wedekind et al (1995) in this study, wedekind and colleagues experimentally tested whether human female odor preferences for male body odor are dependent upon mhc genetic similarity.

A suitable model for such a kind of study is the house mouse, whose two subspecies, mus musculus musculus and m m domesticus, mate and hybridise, forming a long and narrow hybrid zone in europe (boursot et al, 1993, macholán et al, 2003, raufaste et al, 2005, macholán et al, 2007. House mice (mus musculus domesticus) avoid mating with individuals that are genetically similar at the major histocompatibility complex (mhc) mice are able recognize mhc-similar individuals through speci¢c odour cues. Our ‘free mate choice’ trials not only eliminated female preferences, male–male and female–female competition, but also our best guesses of the traits mediating choosers' preferences males mated with their preferred (p) females sired more litters than males mated with their nonpreferred (np) females.

All animals were healthy adults and housed individually in wire cages (40 × 40 × 40 cm 3), and water with vitamins was provided ad libitum the cage environment was maintained at 12 h l: 12 h d (lights on at 08:00), 25 ± 1°c, and 65–92% relative humidity all animal procedures were. Mhc‑based mate preference mhc signaling also facilitates cooperative behavior with present the current evidence for mhc as a signal of relatedness, individuality, genetic mus musculus) mhc disassortative female communal nesting familial ingmt i r p yamazaki et al 1976, 2 1988, 20 2007 21. The scent of a novel male can elicit pregnancy block in recently mated female mice (mus musculus), a phenomenon known as the bruce effect despite abundant literature on the bruce effect in rodents, it remains unclear whether males related to a female’s original mate can induce the bruce effect in out-bred, communally living mice.

the role of mhc relatedness in female lab mouse m musculus mate preference 1 introduction the major histocompatibility complex (mhc) is an extremely polymorphic cluster of genes that encode antigen-presenting molecules of central importance in vertebrate adaptive immunity. the role of mhc relatedness in female lab mouse m musculus mate preference 1 introduction the major histocompatibility complex (mhc) is an extremely polymorphic cluster of genes that encode antigen-presenting molecules of central importance in vertebrate adaptive immunity. the role of mhc relatedness in female lab mouse m musculus mate preference 1 introduction the major histocompatibility complex (mhc) is an extremely polymorphic cluster of genes that encode antigen-presenting molecules of central importance in vertebrate adaptive immunity. the role of mhc relatedness in female lab mouse m musculus mate preference 1 introduction the major histocompatibility complex (mhc) is an extremely polymorphic cluster of genes that encode antigen-presenting molecules of central importance in vertebrate adaptive immunity.
The role of mhc relatedness in female lab mouse m musculus mate preference
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